Protein Details: Neuronal acetylcholine receptor subunit alpha-3

Protein ID

ICDB_Pro_0769

Protein Name

Neuronal acetylcholine receptor subunit alpha-3

Gene Name

CHRNA3

Organism

Bos taurus (Bovine)

Length

495 amino acids

AlphaFoldDB

AF-Q07263-F1-model_v4.pdb

Function

After binding acetylcholine; the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Sequence

MARRSRLRRLLLLLLLPVASTSDAEHRLFERLFEDYNEIIRPVANVSDPVIIQFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYDGAEFMRVPAEKIWKPDIVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPAWVKTIFLNLLPRVMFMTRPASNEGNTQRPRPFYSAELSNLNCFSRIESKVCKEGYPCQDGLCGYCHHRRAKISNFSANLTRSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFILVCILGTAGLFLQPLMTRDDA

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

10.1007/bf02736842; 10.1016/s0014-5793(96)01383-x; 10.1101/gr.2596504; 10.1016/0304-3940(93)90691-d

RefSeq

NP_000740.1